Neuron-Astroglia Cell Fate Decision in the Adult Mouse Hippocampal Neurogenic Niche Is Cell-Intrinsically Controlled by COUP-TFI In Vivo
Summary: In the dentate gyrus (DG) of the mouse hippocampus, neurogenesis and astrogliogenesis persist throughout life.Adult-born neurons and here astrocytes originate from multipotent neural stem cells (NSCs) whose activity is tightly regulated within the neurogenic niche.However, the cell-intrinsic mechanisms controlling neuron-glia NSC fate choi